Assay Detail
Functional
CHEMBL698215
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of tubulin polymerization.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Antitumor agents. 141. Synthesis and biological evaluation of novel thiocolchicine analogs: N-acyl-, N-aroyl-, and N-(substituted benzyl)deacetylthiocolchicines as potent cytotoxic and antimitotic compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.60 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290219 | — | — | 1 | 5.72 |
| CHEMBL34781 | — | — | 1 | 5.68 |
| CHEMBL36073 | — | — | 1 | 5.68 |
| CHEMBL18981 | THIOCOLCHICINE | — | 1 | 5.68 |
| CHEMBL34772 | — | — | 1 | 5.64 |
| CHEMBL416773 | — | — | 1 | 5.64 |
| CHEMBL35647 | — | — | 1 | 5.64 |
| CHEMBL37931 | — | — | 1 | 5.64 |
| CHEMBL37812 | — | — | 1 | 5.62 |
| CHEMBL285869 | — | — | 1 | 5.60 |
| CHEMBL35438 | — | — | 1 | 5.60 |
| CHEMBL284940 | — | — | 1 | 5.55 |
| CHEMBL417869 | — | — | 1 | 5.55 |
| CHEMBL287357 | — | — | 1 | 5.52 |
| CHEMBL35529 | — | — | 1 | 5.50 |
| CHEMBL285750 | — | — | 1 | 5.47 |
| CHEMBL289240 | — | — | 1 | 5.47 |
| CHEMBL35027 | — | — | 1 | - |
| CHEMBL287697 | — | — | 1 | - |
| CHEMBL37785 | — | — | 1 | - |
| CHEMBL35028 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290219 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL34781 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL36073 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL18981 | THIOCOLCHICINE | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL34772 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL416773 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL35647 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL37931 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL37812 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL285869 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL35438 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL284940 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL417869 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL287357 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL35529 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL285750 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL289240 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL35027 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL287697 | — | IC50 | - | nM | - | |
| CHEMBL37785 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL35028 | — | IC50 | > | 40000.0 | nM | - |