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Assay Detail

CHEMBL698229

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Ability to inhibit proliferation in human lymphocytes by mixed lymphocyte reaction (MLR)
ChEMBL ↗
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

ADMET (CHEMBL612558) ↗
Type ADMET

Publication

Immunosuppressive structure-activity relationships of Brequinar and related cinchoninic acid derivatives
Batt DG, Copeland RA, Dowling RL, Gardner TL, Jones EA, Orwat MJ, Pinto DJ, Pitts WJ, Magolda RL, Jaffee BD
Bioorg Med Chem Lett (1995) 5 : 1549 -1554
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 54 7.03 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL38692 — — 1 8.15
CHEMBL289470 — — 1 7.85
CHEMBL38434 BREQUINAR 2.0 1 7.82
CHEMBL39472 — — 1 7.75
CHEMBL38978 — — 1 7.70
CHEMBL39396 — — 1 7.60
CHEMBL288708 — — 1 7.51
CHEMBL38986 — — 1 7.46
CHEMBL38421 — — 1 6.82
CHEMBL39162 — — 1 6.82
CHEMBL40846 — — 1 6.82
CHEMBL39448 — — 1 6.75
CHEMBL36047 — — 1 6.68
CHEMBL40093 — — 1 6.60
CHEMBL39188 — — 1 6.58
CHEMBL39971 — — 1 6.54
CHEMBL43639 — — 1 6.52
CHEMBL41799 — — 1 6.46
CHEMBL290910 — — 1 6.42
CHEMBL416057 — — 1 6.40
CHEMBL38614 — — 1 6.30
CHEMBL418062 — — 1 -
CHEMBL39128 — — 1 -
CHEMBL39151 — — 1 -
CHEMBL39167 — — 1 -
CHEMBL290674 — — 1 -
CHEMBL39325 — — 1 -
CHEMBL287730 — — 1 -
CHEMBL43638 — — 1 -
CHEMBL38620 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL38692 — IC50 = 7.0 nM 8.15
CHEMBL289470 — IC50 = 14.0 nM 7.85
CHEMBL38434 BREQUINAR IC50 = 15.0 nM 7.82
CHEMBL39472 — IC50 = 18.0 nM 7.75
CHEMBL38978 — IC50 = 20.0 nM 7.70
CHEMBL39396 — IC50 = 25.0 nM 7.60
CHEMBL288708 — IC50 = 31.0 nM 7.51
CHEMBL38986 — IC50 = 35.0 nM 7.46
CHEMBL38421 — IC50 = 150.0 nM 6.82
CHEMBL39162 — IC50 = 150.0 nM 6.82
CHEMBL40846 — IC50 = 150.0 nM 6.82
CHEMBL39448 — IC50 = 180.0 nM 6.75
CHEMBL36047 — IC50 = 210.0 nM 6.68
CHEMBL40093 — IC50 = 250.0 nM 6.60
CHEMBL39188 — IC50 = 260.0 nM 6.58
CHEMBL39971 — IC50 = 290.0 nM 6.54
CHEMBL43639 — IC50 = 300.0 nM 6.52
CHEMBL41799 — IC50 = 350.0 nM 6.46
CHEMBL290910 — IC50 = 380.0 nM 6.42
CHEMBL416057 — IC50 = 400.0 nM 6.40
CHEMBL38614 — IC50 = 500.0 nM 6.30
CHEMBL39191 — IC50 > 500.0 nM -
CHEMBL291268 — IC50 > 500.0 nM -
CHEMBL288852 — IC50 > 500.0 nM -
CHEMBL38669 — IC50 > 500.0 nM -
CHEMBL288381 — IC50 > 500.0 nM -
CHEMBL38639 — IC50 > 500.0 nM -
CHEMBL38242 — IC50 > 500.0 nM -
CHEMBL289854 — IC50 > 500.0 nM -
CHEMBL41719 — IC50 > 500.0 nM -
CHEMBL38953 — IC50 > 500.0 nM -
CHEMBL39397 — IC50 > 500.0 nM -
CHEMBL433445 — IC50 > 500.0 nM -
CHEMBL38440 — IC50 > 500.0 nM -
CHEMBL288137 — IC50 > 500.0 nM -
CHEMBL43521 — IC50 > 500.0 nM -
CHEMBL289555 — IC50 > 500.0 nM -
CHEMBL36981 — IC50 > 500.0 nM -
CHEMBL40182 — IC50 > 500.0 nM -
CHEMBL38997 — IC50 > 500.0 nM -
CHEMBL440660 — IC50 > 500.0 nM -
CHEMBL38620 — IC50 > 500.0 nM -
CHEMBL43638 — IC50 > 500.0 nM -
CHEMBL287730 — IC50 > 500.0 nM -
CHEMBL39325 — IC50 > 500.0 nM -
CHEMBL290674 — IC50 > 500.0 nM -
CHEMBL39167 — IC50 > 500.0 nM -
CHEMBL39151 — IC50 > 500.0 nM -
CHEMBL39128 — IC50 > 500.0 nM -
CHEMBL418062 — IC50 > 500.0 nM -