Assay Detail
Functional
CHEMBL698276
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for 50% inhibition of cholesterol synthesis in human skin fibroblasts.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.49 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175236 | — | — | 1 | 7.72 |
| CHEMBL690 | PRAVASTATIN SODIUM | 4.0 | 1 | 5.51 |
| CHEMBL101621 | — | — | 1 | 5.05 |
| CHEMBL318784 | — | — | 1 | 4.96 |
| CHEMBL98469 | — | — | 1 | 4.19 |
| CHEMBL101721 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175236 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL690 | PRAVASTATIN SODIUM | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL101621 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL318784 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL98469 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL101721 | — | IC50 | = | 327000.0 | nM | - |