Assay Detail
Functional
CHEMBL698305
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for anti-platelet activity by measuring its inhibitory effect on human platelet rich plasma (PRP) aggregated with U-46,619.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of new 3,4-disubstituted pyrrolidines as thromboxane A2/prostaglandin H2 (TP) receptor antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.05 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30024 | — | — | 1 | 7.89 |
| CHEMBL116088 | — | — | 1 | 6.22 |
| CHEMBL263442 | — | — | 1 | 5.89 |
| CHEMBL434030 | — | — | 1 | 5.52 |
| CHEMBL119624 | — | — | 1 | 5.44 |
| CHEMBL116852 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30024 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL116088 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL263442 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL434030 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL119624 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL116852 | — | IC50 | = | 4700.0 | nM | 5.33 |