Assay Detail
Functional
CHEMBL698311
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In vitro antagonist activity, determined by 50% inhibition of PAF-induced platelet aggregation of human platelet rich plasma when challenged with PAF
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Dual antagonists of platelet activating factor and histamine. 3. Synthesis, biological activity and conformational implications of substituted N-acyl-bis-arylcycloheptapiperazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 5.46 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280164 | APAFANT | 2.0 | 1 | 7.40 |
| CHEMBL2448125 | — | — | 1 | 6.68 |
| CHEMBL326821 | — | — | 1 | 6.40 |
| CHEMBL332566 | — | — | 1 | 6.38 |
| CHEMBL10971 | SCH-37370 | — | 1 | 6.21 |
| CHEMBL117289 | — | — | 1 | 6.18 |
| CHEMBL2111767 | — | — | 1 | 5.89 |
| CHEMBL326289 | — | — | 1 | 5.85 |
| CHEMBL326978 | — | — | 1 | 5.75 |
| CHEMBL116935 | — | — | 1 | 5.62 |
| CHEMBL324336 | — | — | 1 | 4.92 |
| CHEMBL117745 | — | — | 1 | 4.89 |
| CHEMBL325909 | — | — | 1 | 4.85 |
| CHEMBL333594 | — | — | 1 | 4.85 |
| CHEMBL116144 | — | — | 1 | 4.82 |
| CHEMBL331159 | — | — | 1 | 4.58 |
| CHEMBL118807 | — | — | 1 | 4.55 |
| CHEMBL1172 | DESLORATADINE | 4.0 | 1 | 4.51 |
| CHEMBL331603 | — | — | 1 | 4.48 |
| CHEMBL334318 | — | — | 1 | 4.39 |
| CHEMBL325470 | — | — | 1 | - |
| CHEMBL332936 | — | — | 1 | - |
| CHEMBL410734 | — | — | 1 | - |
| CHEMBL420316 | — | — | 1 | - |
| CHEMBL505 | CHLORPHENIRAMINE | 4.0 | 1 | - |
| CHEMBL998 | LORATADINE | 4.0 | 1 | - |
| CHEMBL325718 | — | — | 1 | - |
| CHEMBL117406 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280164 | APAFANT | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2448125 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL326821 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL332566 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL10971 | SCH-37370 | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL117289 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL2111767 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL326289 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL326978 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL116935 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL324336 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL117745 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL325909 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL333594 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL116144 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL331159 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL118807 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL1172 | DESLORATADINE | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL331603 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL334318 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL325470 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL332936 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL410734 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL420316 | — | IC50 | >= | 50000.0 | nM | - |
| CHEMBL505 | CHLORPHENIRAMINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL998 | LORATADINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL325718 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL117406 | — | IC50 | >= | 23000.0 | nM | - |