Assay Detail
Functional
CHEMBL698333
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Inhibitory concentration against Human Jurkat leukemia (JLC) cell proliferation
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antitumor properties of N-[2-(dimethylamino)ethyl]carboxamide derivatives of fused tetracyclic quinolines and quinoxalines: a new class of putative topoisomerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.58 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.25 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.02 |
| CHEMBL64927 | — | — | 1 | 7.47 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 7.43 |
| CHEMBL62347 | — | — | 1 | 6.82 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.80 |
| CHEMBL303785 | — | — | 1 | 6.77 |
| CHEMBL64036 | — | — | 1 | 6.75 |
| CHEMBL64382 | — | — | 1 | 6.52 |
| CHEMBL293859 | — | — | 1 | 6.50 |
| CHEMBL65436 | — | — | 1 | 6.43 |
| CHEMBL60437 | — | — | 1 | 6.37 |
| CHEMBL62522 | — | — | 1 | 6.35 |
| CHEMBL63120 | — | — | 1 | 6.26 |
| CHEMBL9940 | — | — | 1 | 6.24 |
| CHEMBL418668 | — | — | 1 | 6.07 |
| CHEMBL60552 | — | — | 1 | 6.01 |
| CHEMBL62789 | — | — | 1 | 5.96 |
| CHEMBL62763 | — | — | 1 | 5.85 |
| CHEMBL291885 | — | — | 1 | 5.82 |
| CHEMBL62883 | — | — | 1 | 5.58 |
| CHEMBL64307 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL64927 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL43 | AMSACRINE | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL62347 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL303785 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL64036 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL64382 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL293859 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL65436 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL60437 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL62522 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL63120 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL9940 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL418668 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL60552 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL62789 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL62763 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL291885 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL62883 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL64307 | — | IC50 | > | 2000.0 | nM | - |