Assay Detail
Functional
CHEMBL698335
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration required to reduce cell number to 50% of control cultures in JLc(Jurkat human leukemia)
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dicationic bis(9-methylphenazine-1-carboxamides): relationships between biological activity and linker chain structure for a series of potent topoisomerase targeted anticancer drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.50 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283677 | — | — | 1 | 10.10 |
| CHEMBL30424 | — | — | 1 | 9.74 |
| CHEMBL285349 | — | — | 1 | 9.62 |
| CHEMBL31879 | — | — | 1 | 9.22 |
| CHEMBL30912 | — | — | 1 | 9.22 |
| CHEMBL31400 | ELINAFIDE | 2.0 | 1 | 9.15 |
| CHEMBL30628 | — | — | 1 | 8.96 |
| CHEMBL286429 | — | — | 1 | 8.89 |
| CHEMBL283010 | — | — | 1 | 8.89 |
| CHEMBL30843 | — | — | 1 | 8.77 |
| CHEMBL31790 | — | — | 1 | 8.28 |
| CHEMBL30232 | — | — | 1 | 8.25 |
| CHEMBL285322 | — | — | 1 | 8.06 |
| CHEMBL32741 | — | — | 1 | 7.96 |
| CHEMBL31769 | — | — | 1 | 7.80 |
| CHEMBL29944 | — | — | 1 | 7.34 |
| CHEMBL29602 | — | — | 1 | 7.34 |
| CHEMBL287582 | — | — | 1 | 7.17 |
| CHEMBL286942 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283677 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL30424 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL285349 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL31879 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL30912 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL31400 | ELINAFIDE | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL30628 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL286429 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL283010 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL30843 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL31790 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL30232 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL285322 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL32741 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL31769 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL29944 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL29602 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL287582 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL286942 | — | IC50 | = | 207.0 | nM | 6.68 |