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Assay Detail

CHEMBL698514

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against inosine monophosphate dehydrogenase IMPDH type I
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Inosine-5'-monophosphate dehydrogenase 1 (CHEMBL1822)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.
Watterson SH, Carlsen M, Dhar TG, Shen Z, Pitts WJ, Guo J, Gu HH, Norris D, Chorba J, Chen P, Cheney D, Witmer M, Fleener CA, Rouleau K, Townsend R, Hollenbaugh DL, Iwanowicz EJ.
Bioorg Med Chem Lett (2003) 13 : 543 -546
PubMed 12565968 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 8 7.13 7.34

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL152988 1 7.34
CHEMBL65013 1 7.26
CHEMBL347721 1 7.26
CHEMBL866 MYCOPHENOLIC ACID 4.0 1 7.26
CHEMBL358876 1 7.08
CHEMBL152959 1 7.05
CHEMBL23843 1 7.00
CHEMBL150777 1 6.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL152988 IC50 = 46.0 nM 7.34
CHEMBL65013 IC50 = 55.0 nM 7.26
CHEMBL347721 IC50 = 55.0 nM 7.26
CHEMBL866 MYCOPHENOLIC ACID IC50 = 55.0 nM 7.26
CHEMBL358876 IC50 = 83.0 nM 7.08
CHEMBL152959 IC50 = 90.0 nM 7.05
CHEMBL23843 IC50 = 99.0 nM 7.00
CHEMBL150777 IC50 = 150.0 nM 6.82