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Assay Detail

CHEMBL698516

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against human Inosine-5'-monophosphate dehydrogenase 1 (IMPDH type I)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Inosine-5'-monophosphate dehydrogenase 1 (CHEMBL1822)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel mycophenolic adenine bis(phosphonate) analogues as potential differentiation agents against human leukemia.
Pankiewicz KW, Lesiak-Watanabe KB, Watanabe KA, Patterson SE, Jayaram HN, Yalowitz JA, Miller MD, Seidman M, Majumdar A, Prehna G, Goldstein BM.
J Med Chem (2002) 45 : 703 -712
PubMed 11806722 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 9 6.44 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL866 MYCOPHENOLIC ACID 4.0 1 7.40
CHEMBL3144029 1 6.96
CHEMBL3144028 1 6.52
CHEMBL608195 1 6.48
CHEMBL410744 1 6.48
CHEMBL2311206 1 6.28
CHEMBL608194 1 6.18
CHEMBL162782 1 6.05
CHEMBL348359 1 5.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL866 MYCOPHENOLIC ACID Ki = 40.0 nM 7.40
CHEMBL3144029 Ki = 110.0 nM 6.96
CHEMBL3144028 Ki = 300.0 nM 6.52
CHEMBL608195 Ki = 330.0 nM 6.48
CHEMBL410744 Ki = 330.0 nM 6.48
CHEMBL2311206 Ki = 520.0 nM 6.28
CHEMBL608194 Ki = 660.0 nM 6.18
CHEMBL162782 Ki = 890.0 nM 6.05
CHEMBL348359 Ki = 2300.0 nM 5.64