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Assay Detail

CHEMBL698521

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of inosine-5'-monophosphate dehydrogenase 2.
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cricetulus griseus
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Inosine-5'-monophosphate dehydrogenase 2 (CHEMBL2002)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety.
Iwanowicz EJ, Watterson SH, Guo J, Pitts WJ, Murali Dhar TG, Shen Z, Chen P, Gu HH, Fleener CA, Rouleau KA, Cheney DL, Townsend RM, Hollenbaugh DL.
Bioorg Med Chem Lett (2003) 13 : 2059 -2063
PubMed 12781195 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 49 7.16 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL23843 1 8.10
CHEMBL25138 1 8.00
CHEMBL64830 1 7.80
CHEMBL65013 1 7.72
CHEMBL64639 1 7.70
CHEMBL302827 1 7.68
CHEMBL62748 1 7.68
CHEMBL305374 1 7.55
CHEMBL64609 1 7.55
CHEMBL63122 1 7.39
CHEMBL62934 1 7.39
CHEMBL292258 1 7.37
CHEMBL62496 1 7.35
CHEMBL293162 1 7.33
CHEMBL24866 1 7.30
CHEMBL24092 1 7.26
CHEMBL433062 1 7.12
CHEMBL62986 1 7.06
CHEMBL302609 1 7.04
CHEMBL62467 1 7.00
CHEMBL293640 1 7.00
CHEMBL65737 1 6.72
CHEMBL65738 1 6.68
CHEMBL60730 1 6.62
CHEMBL62747 1 6.51
CHEMBL62377 1 6.39
CHEMBL302224 1 6.30
CHEMBL62232 1 6.19
CHEMBL302626 1 5.80
CHEMBL62691 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL23843 IC50 = 8.0 nM 8.10
CHEMBL25138 IC50 = 10.0 nM 8.00
CHEMBL64830 IC50 = 16.0 nM 7.80
CHEMBL65013 IC50 = 19.0 nM 7.72
CHEMBL64639 IC50 = 20.0 nM 7.70
CHEMBL302827 IC50 = 21.0 nM 7.68
CHEMBL62748 IC50 = 21.0 nM 7.68
CHEMBL305374 IC50 = 28.0 nM 7.55
CHEMBL64609 IC50 = 28.0 nM 7.55
CHEMBL63122 IC50 = 41.0 nM 7.39
CHEMBL62934 IC50 = 41.0 nM 7.39
CHEMBL292258 IC50 = 43.0 nM 7.37
CHEMBL62496 IC50 = 45.0 nM 7.35
CHEMBL293162 IC50 = 47.0 nM 7.33
CHEMBL24866 IC50 = 50.0 nM 7.30
CHEMBL24092 IC50 = 55.0 nM 7.26
CHEMBL433062 IC50 = 76.0 nM 7.12
CHEMBL62986 IC50 = 88.0 nM 7.06
CHEMBL302609 IC50 = 91.0 nM 7.04
CHEMBL62467 IC50 = 100.0 nM 7.00
CHEMBL293640 IC50 = 100.0 nM 7.00
CHEMBL65737 IC50 = 190.0 nM 6.72
CHEMBL65738 IC50 = 210.0 nM 6.68
CHEMBL60730 IC50 = 240.0 nM 6.62
CHEMBL62747 IC50 = 310.0 nM 6.51
CHEMBL62377 IC50 = 410.0 nM 6.39
CHEMBL302224 IC50 = 500.0 nM 6.30
CHEMBL62232 IC50 = 640.0 nM 6.19
CHEMBL302626 IC50 = 1600.0 nM 5.80
CHEMBL65447 IC50 > 5000.0 nM -
CHEMBL62944 IC50 > 1600.0 nM -
CHEMBL27985 IC50 > 5000.0 nM -
CHEMBL293175 IC50 > 5000.0 nM -
CHEMBL63968 IC50 > 5000.0 nM -
CHEMBL62351 IC50 > 5000.0 nM -
CHEMBL63466 IC50 > 2000.0 nM -
CHEMBL62355 IC50 > 5000.0 nM -
CHEMBL62622 IC50 > 10000.0 nM -
CHEMBL63501 IC50 > 2000.0 nM -
CHEMBL62457 IC50 > 5000.0 nM -
CHEMBL303341 IC50 > 5000.0 nM -
CHEMBL65970 IC50 > 340.0 nM -
CHEMBL64753 IC50 > 2000.0 nM -
CHEMBL62851 IC50 > 1600.0 nM -
CHEMBL63529 IC50 > 57.0 nM -
CHEMBL62619 IC50 > 5000.0 nM -
CHEMBL64898 IC50 > 5000.0 nM -
CHEMBL279957 IC50 > 5000.0 nM -
CHEMBL62691 IC50 > 5000.0 nM -