Compound Detail
CHEMBL24866
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Basic Information
| ChEMBL ID | CHEMBL24866 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XUGKKEMTOBDOSZ-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
366.2
MW (Da)
2.96
ALogP
4
HBA
2
HBD
84.2
PSA (Ų)
0.80
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Inosine-5'-monophosphate dehydrogenase 2 CHEMBL2002 | IC50 | 7.3 | 7.3 | 50.0 | 2 |
| CCRF-CEM CHEMBL382 | IC50 | 5.26 | 5.26 | 5500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Inosine-5'-monophosphate dehydrogenase 2 | IC50 | = | 50.0 | nM | 7.3 | Inhibition of inosine-5'-monophosphate dehydrogenase 2. | 12781195 |
| Inosine-5'-monophosphate dehydrogenase 2 | IC50 | = | 50.0 | nM | 7.3 | Inhibition of human Inosine-5'-monophosphate dehydrogenase 2 | 11965381 |
| CCRF-CEM | IC50 | = | 5500.0 | nM | 5.26 | Inhibition of CEM cell proliferation. | 12781195 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12781195 | 10.1016/s0960-894x(03)00258-0 | Inosine-5'-monophosphate dehydrogenase 2 | 1 |
| 12781195 | 10.1016/s0960-894x(03)00258-0 | CCRF-CEM | 1 |
| 11965381 | 10.1016/s0960-894x(02)00132-4 | Inosine-5'-monophosphate dehydrogenase 2 | 1 |
Data from ChEMBL 36 via Core Engine