Assay Detail
Binding
CHEMBL698522
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Inhibition of human Inosine-5'-monophosphate dehydrogenase 2
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Inosine-5'-monophosphate dehydrogenase 2 (CHEMBL2002) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel diamide-based inhibitors of IMPDH.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.30 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25138 | — | — | 1 | 8.00 |
| CHEMBL416932 | — | — | 1 | 7.75 |
| CHEMBL27777 | — | — | 1 | 7.72 |
| CHEMBL25179 | — | — | 1 | 7.52 |
| CHEMBL25681 | — | — | 1 | 7.52 |
| CHEMBL24840 | — | — | 1 | 7.33 |
| CHEMBL24866 | — | — | 1 | 7.30 |
| CHEMBL283256 | — | — | 1 | 7.28 |
| CHEMBL24092 | — | — | 1 | 7.26 |
| CHEMBL25027 | — | — | 1 | 7.13 |
| CHEMBL24737 | — | — | 1 | 6.40 |
| CHEMBL25689 | — | — | 1 | 6.36 |
| CHEMBL27327 | — | — | 1 | - |
| CHEMBL279957 | — | — | 1 | - |
| CHEMBL25087 | — | — | 1 | - |
| CHEMBL27985 | — | — | 1 | - |
| CHEMBL280194 | — | — | 1 | - |
| CHEMBL282697 | — | — | 1 | - |
| CHEMBL280799 | — | — | 1 | - |
| CHEMBL416379 | — | — | 1 | - |
| CHEMBL28089 | — | — | 1 | - |
| CHEMBL27504 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25138 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL416932 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL27777 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL25179 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL25681 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL24840 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL24866 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL283256 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL24092 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL25027 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL24737 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL25689 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL27327 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL279957 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL25087 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL27985 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL280194 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL282697 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL280799 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL416379 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL28089 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL27504 | — | IC50 | > | 10000.0 | nM | - |