Assay Detail
Functional
CHEMBL698532
Review assay metadata, readout intent, target linkage, and publication context from the same page.
PGI-2 agonistic activity by measuring inhibition of 4 uM ADP-induced human platelet aggregation
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pharmacological evaluation of combined PGI2 agonists/thromboxane synthase inhibitors. I
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.75 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494 | ILOPROST | 4.0 | 1 | 8.85 |
| CHEMBL11211 | — | — | 1 | 7.24 |
| CHEMBL11765 | — | — | 1 | 6.89 |
| CHEMBL268477 | AP-227 | — | 1 | 6.82 |
| CHEMBL11779 | — | — | 1 | 6.82 |
| CHEMBL11088 | — | — | 1 | 6.64 |
| CHEMBL429786 | — | — | 1 | 6.62 |
| CHEMBL11291 | — | — | 1 | 6.60 |
| CHEMBL12020 | — | — | 1 | 6.50 |
| CHEMBL11407 | — | — | 1 | 6.36 |
| CHEMBL12032 | — | — | 1 | 6.32 |
| CHEMBL11563 | — | — | 1 | 6.24 |
| CHEMBL12340 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494 | ILOPROST | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL11211 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL11765 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL268477 | AP-227 | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL11779 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL11088 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL429786 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL11291 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL12020 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL11407 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL12032 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL11563 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL12340 | — | IC50 | = | 1400.0 | nM | 5.85 |