Assay Detail
Functional
CHEMBL698626
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In vitro anticellular activity tested against HeLa S3 cells
53
Total Activities
52
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and antitumor activity of novel mitomycin derivatives containing functional groups at the C-6-methyl position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 53 | 5.66 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298359 | MITOMYCIN A | 3.0 | 1 | 8.62 |
| CHEMBL50702 | — | — | 1 | 6.92 |
| CHEMBL50341 | — | — | 1 | 6.92 |
| CHEMBL301783 | — | — | 1 | 6.72 |
| CHEMBL54010 | — | — | 1 | 6.57 |
| CHEMBL3707130 | — | — | 1 | 6.51 |
| CHEMBL51172 | — | — | 1 | 6.16 |
| CHEMBL50756 | — | — | 1 | 6.12 |
| CHEMBL54187 | — | — | 1 | 6.11 |
| CHEMBL3707132 | — | — | 1 | 6.09 |
| CHEMBL52786 | — | — | 1 | 6.02 |
| CHEMBL51035 | — | — | 1 | 6.01 |
| CHEMBL53880 | — | — | 1 | 6.00 |
| CHEMBL300181 | — | — | 1 | 5.96 |
| CHEMBL3707126 | — | — | 1 | 5.96 |
| CHEMBL53231 | — | — | 1 | 5.96 |
| CHEMBL53612 | — | — | 1 | 5.96 |
| CHEMBL3707131 | — | — | 1 | 5.89 |
| CHEMBL52575 | — | — | 1 | 5.85 |
| CHEMBL54072 | — | — | 1 | 5.75 |
| CHEMBL50791 | — | — | 1 | 5.66 |
| CHEMBL53341 | — | — | 1 | 5.66 |
| CHEMBL298868 | — | — | 1 | 5.66 |
| CHEMBL50939 | — | — | 1 | 5.64 |
| CHEMBL52743 | — | — | 1 | 5.64 |
| CHEMBL51032 | — | — | 1 | 5.60 |
| CHEMBL50743 | — | — | 1 | 5.60 |
| CHEMBL52686 | — | — | 1 | 5.58 |
| CHEMBL52061 | — | — | 1 | 5.31 |
| CHEMBL299342 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298359 | MITOMYCIN A | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL50702 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL50341 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL301783 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL54010 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL3707130 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL51172 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL50756 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL54187 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL3707132 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL52786 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL51035 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL53880 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL53231 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3707126 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL53612 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL300181 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3707131 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL52575 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL54072 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL298868 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL50791 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL53341 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL52743 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL50939 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL50743 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL51032 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL52686 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL52061 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL299342 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL52844 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL297710 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL53689 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL445326 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL53477 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL53823 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL53522 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL52336 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL52787 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL301968 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL50043 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL54236 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL50796 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL50153 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL416473 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL409434 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL53588 | — | IC50 | > | 82000.0 | nM | - |
| CHEMBL416473 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL49985 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3707127 | — | IC50 | > | 100000.0 | nM | - |