Assay Detail
Functional
CHEMBL698635
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Effective concentration required to increase the oxidation of lactate in cellular assay using Human Skin Fibroblasts
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Secondary amides of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.80 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL316388 | — | — | 1 | 7.24 |
| CHEMBL309697 | — | — | 1 | 6.80 |
| CHEMBL304292 | — | — | 1 | 6.60 |
| CHEMBL419846 | — | — | 1 | 6.33 |
| CHEMBL79457 | — | — | 1 | 5.95 |
| CHEMBL93045 | — | — | 1 | 5.27 |
| CHEMBL313843 | — | — | 1 | 4.89 |
| CHEMBL309318 | — | — | 1 | 4.60 |
| CHEMBL311859 | — | — | 1 | 4.54 |
| CHEMBL306823 | SODIUM DICHLOROACETATE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL316388 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL309697 | — | EC50 | = | 159.0 | nM | 6.80 |
| CHEMBL304292 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL419846 | — | EC50 | = | 473.0 | nM | 6.33 |
| CHEMBL79457 | — | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL93045 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL313843 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL309318 | — | EC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL311859 | — | EC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL306823 | SODIUM DICHLOROACETATE | EC50 | = | 130000.0 | nM | - |