Assay Detail
Binding
CHEMBL698808
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Histone deacetylase 4 in mammalian cells.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.13 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144205 | — | — | 1 | 9.52 |
| CHEMBL145110 | — | — | 1 | 8.57 |
| CHEMBL343448 | ROMIDEPSIN | 4.0 | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144205 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL145110 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL343448 | ROMIDEPSIN | IC50 | = | 510.0 | nM | 6.29 |