Assay Detail
Functional
CHEMBL698823
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against U-46,619-induced aggregation of platelet rich plasma (PRP)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 2. Synthesis and biological activity of 8-(benzenesulfonamido)-7-(3-pyridinyl)octaonic acid and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.86 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL544150 | — | — | 1 | 6.70 |
| CHEMBL544377 | — | — | 1 | 6.22 |
| CHEMBL557427 | — | — | 1 | 5.68 |
| CHEMBL556044 | — | — | 1 | 5.60 |
| CHEMBL555812 | — | — | 1 | 5.54 |
| CHEMBL8273 | SULOTROBAN | 2.0 | 1 | 5.40 |
| CHEMBL541097 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL544150 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL544377 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL557427 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL556044 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL555812 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL8273 | SULOTROBAN | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL541097 | — | IC50 | > | 10000.0 | nM | - |