Assay Detail
Functional
CHEMBL698828
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Compound was evaluated for the inhibition of CRF-stimulated cyclic adenosine monophosphate production
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.34 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45281 | — | — | 1 | 7.00 |
| CHEMBL75859 | — | — | 1 | 6.60 |
| CHEMBL77006 | — | — | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45281 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL75859 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL77006 | — | IC50 | = | 3700.0 | nM | 5.43 |