Assay Detail
Functional
CHEMBL698837
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In vitro inhibition of U 46619 induced aggregation of human PRP
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 1. (+/-)-(3-pyridinylbicycloheptyl)alkanoic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.23 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL430965 | — | — | 1 | 5.57 |
| CHEMBL280728 | RIDOGREL | 2.0 | 1 | 5.55 |
| CHEMBL51158 | — | — | 1 | 5.15 |
| CHEMBL51875 | — | — | 1 | 4.96 |
| CHEMBL298130 | — | — | 1 | 4.92 |
| CHEMBL297712 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL430965 | — | IC50 | = | 2720.0 | nM | 5.57 |
| CHEMBL280728 | RIDOGREL | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL51158 | — | IC50 | = | 7150.0 | nM | 5.15 |
| CHEMBL51875 | — | IC50 | = | 10850.0 | nM | 4.96 |
| CHEMBL298130 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL297712 | — | IC50 | > | 30000.0 | nM | - |