Assay Detail
Binding
CHEMBL698878
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Compound tested for the inhibition of human isoleucyl-tRNA synthetase
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Isoleucine--tRNA ligase, cytoplasmic (CHEMBL3235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of a series of novel thiazoles as inhibitors of aminoacyl-tRNA synthetases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.66 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL125075 | — | — | 1 | 7.47 |
| CHEMBL538163 | — | — | 1 | 7.00 |
| CHEMBL123796 | — | — | 1 | 6.92 |
| CHEMBL333001 | — | — | 1 | 6.70 |
| CHEMBL125820 | — | — | 1 | 6.52 |
| CHEMBL264002 | — | — | 1 | 6.48 |
| CHEMBL125221 | — | — | 1 | 6.43 |
| CHEMBL340359 | — | — | 1 | 6.40 |
| CHEMBL126515 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL125075 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL538163 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL123796 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL333001 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL125820 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL264002 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL125221 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL340359 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL126515 | — | IC50 | = | 1020.0 | nM | 5.99 |