Assay Detail
Binding
CHEMBL698879
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Compound was evaluated for its inhibitory activity against Isoleucyl-tRNA synthetase from rat liver
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Analogues of SB-203207 as inhibitors of tRNA synthetases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.95 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74755 | — | — | 1 | 8.54 |
| CHEMBL74395 | — | — | 1 | 8.38 |
| CHEMBL74872 | — | — | 1 | 7.77 |
| CHEMBL309004 | — | — | 1 | 7.60 |
| CHEMBL421500 | — | — | 1 | 7.17 |
| CHEMBL73465 | — | — | 1 | 6.30 |
| CHEMBL305843 | — | — | 1 | 5.21 |
| CHEMBL74343 | — | — | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74755 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL74395 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL74872 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL309004 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL421500 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL73465 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL305843 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL74343 | — | IC50 | = | 22300.0 | nM | 4.65 |