Assay Detail
Binding
CHEMBL698884
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Inhibition of Glycosidases (isomaltase)in rat intestinal brush border membranes by D-glucose oxidase-peroxidase method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
N-alkylated nitrogen-in-the-ring sugars: conformational basis of inhibition of glycosidases and HIV-1 replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.12 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307429 | DUVOGLUSTAT | 2.0 | 1 | 6.52 |
| CHEMBL1029 | MIGLUSTAT | 4.0 | 1 | 5.57 |
| CHEMBL75971 | — | — | 1 | 5.36 |
| CHEMBL80254 | — | — | 1 | 5.24 |
| CHEMBL312653 | — | — | 1 | 4.04 |
| CHEMBL80148 | — | — | 1 | 4.00 |
| CHEMBL77918 | — | — | 1 | - |
| CHEMBL310229 | — | — | 1 | - |
| CHEMBL310231 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307429 | DUVOGLUSTAT | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1029 | MIGLUSTAT | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL75971 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL80254 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL312653 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL80148 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL77918 | — | IC50 | < | 50000.0 | nM | - |
| CHEMBL310229 | — | IC50 | = | 340000.0 | nM | - |
| CHEMBL310231 | — | IC50 | < | 50000.0 | nM | - |