Assay Detail
Functional
CHEMBL698999
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of leukotriene synthesis was assessed from inhibitory activity against human PMN.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
A new class of leukotriene biosynthesis inhibitors: The development of ((4-(4-chlorophenyl)-1-(4-(2-quinolinylmethoxy)phenyl)butyl)thio)acetic acid, L-674,636
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.35 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422872 | AZD-4769 | 1.0 | 1 | 8.52 |
| CHEMBL32842 | — | — | 1 | 8.15 |
| CHEMBL157306 | — | — | 1 | 7.52 |
| CHEMBL160840 | — | — | 1 | 7.10 |
| CHEMBL424339 | — | — | 1 | 7.05 |
| CHEMBL8747 | REV-5901 | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422872 | AZD-4769 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL32842 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL157306 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL160840 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL424339 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL8747 | REV-5901 | IC50 | = | 1800.0 | nM | 5.75 |