Compound Detail
CHEMBL422872
AZD-4769 Phase I
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Phase I
Basic Information
| ChEMBL ID | CHEMBL422872 |
| Name | AZD-4769 |
| Phase | Phase I |
| Structure Type | MOL |
| InChI Key | JOIXGLLMSDPZDN-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
6
Known Names
1
Mechanisms
Molecular Properties
457.6
MW (Da)
6.70
ALogP
4
HBA
1
HBD
59.4
PSA (Ų)
0.27
QED
1
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Epidermal growth factor receptor erbB1 inhibitor | INHIBITOR | Epidermal growth factor receptor | ✓ | ✓ |
Activity Summary
IC50 2 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase CHEMBL312 | IC50 | 7.16 | 7.16 | 70.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 3.0 | nM | 8.52 | Inhibition of leukotriene synthesis was assessed from inhibitory activity agains... | - |
| Polyunsaturated fatty acid 5-lipoxygenase | IC50 | = | 70.0 | nM | 7.16 | Inhibition of 5-LOX in indomethacin stimulated rat PMNL cells assessed as reduct... | 28784429 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(01)81169-0 | Unchecked | 1 |
| 28784429 | 10.1016/j.ejmech.2017.07.019 | Polyunsaturated fatty acid 5-lipoxygenase | 1 |
Data from ChEMBL 36 via Core Engine