Assay Detail
Functional
CHEMBL699058
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Concentration required to inhibit the growth of HeLa S3 cells after 1 hour.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Studies on the active metabolite (DU-86) of KW-2189, a novel derivative of duocarmycin
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.17 | 10.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35670 | — | — | 1 | 10.35 |
| CHEMBL304500 | — | — | 1 | 8.85 |
| CHEMBL303615 | — | — | 1 | 7.44 |
| CHEMBL68711 | — | — | 1 | 6.05 |
| CHEMBL69063 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35670 | — | IC50 | = | 0.045 | nM | 10.35 |
| CHEMBL304500 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL303615 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL68711 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL69063 | — | IC50 | = | 0.0045 | nM | - |