Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL699152

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of ADP-induced human platelet aggregation.
18
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 1 — Organism
Curated By Expert

Target

Homo sapiens (CHEMBL372)
Type ORGANISM
Organism Homo sapiens

Publication

Nonpeptide GPIIb/IIIa inhibitors. 10. Centrally constrained alpha-sulfonamides are potent inhibitors of platelet aggregation
Egbertson M, Hartman G, Gould R, Bednar B, Bednar R, Cook J, Gaul S, Holahan M, Libby L, Lynch J, Lynch R, Sitko G, Stranieri M, Vassallo L
Bioorg Med Chem Lett (1996) 6 : 2519 -2524
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 7.96 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL85064 1 8.40
CHEMBL84259 1 8.15
CHEMBL314622 1 8.15
CHEMBL298589 1 8.10
CHEMBL313176 1 8.10
CHEMBL315065 2 8.05
CHEMBL310294 1 8.05
CHEMBL311734 1 8.05
CHEMBL83015 1 8.00
CHEMBL916 TIROFIBAN 4.0 1 7.96
CHEMBL309742 1 7.89
CHEMBL82862 1 7.85
CHEMBL82689 1 7.82
CHEMBL79294 1 7.82
CHEMBL84774 1 7.80
CHEMBL82839 1 7.72
CHEMBL32960 1 7.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL85064 IC50 = 4.0 nM 8.40
CHEMBL314622 IC50 = 7.0 nM 8.15
CHEMBL84259 IC50 = 7.0 nM 8.15
CHEMBL298589 IC50 = 8.0 nM 8.10
CHEMBL313176 IC50 = 8.0 nM 8.10
CHEMBL311734 IC50 = 9.0 nM 8.05
CHEMBL310294 IC50 = 9.0 nM 8.05
CHEMBL315065 IC50 = 9.0 nM 8.05
CHEMBL83015 IC50 = 10.0 nM 8.00
CHEMBL916 TIROFIBAN IC50 = 11.0 nM 7.96
CHEMBL309742 IC50 = 13.0 nM 7.89
CHEMBL82862 IC50 = 14.0 nM 7.85
CHEMBL315065 IC50 = 14.0 nM 7.85
CHEMBL79294 IC50 = 15.0 nM 7.82
CHEMBL82689 IC50 = 15.0 nM 7.82
CHEMBL84774 IC50 = 16.0 nM 7.80
CHEMBL82839 IC50 = 19.0 nM 7.72
CHEMBL32960 IC50 = 27.0 nM 7.57