Assay Detail

CHEMBL699243

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity towards rats Histamine type 3 (H3) receptor

ChEMBL ↗

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Target

Histamine H3 receptor (CHEMBL4124) ↗

Open DB target context

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Histamine H3 receptor (CHEMBL4124) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Histamine H3 receptor

CHEMBL4124

Anchored from Assay target.

Protein identity Histamine H3 receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Histamine H3 receptor (CHEMBL4124) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Synthesis and evaluation of potent pyrrolidine H(3) antagonists.

Vasudevan A, Conner SE, Gentles RG, Faghih R, Liu H, Dwight W, Ireland L, Kang CH, Esbenshade TA, Bennani YL, Hancock AA.
Bioorg Med Chem Lett (2002) 12 : 3055 -3058
PubMed 12372500 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	8.70	8.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL62803	—	—	1	8.70

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL62803	—	Ki	=	2.0	nM	8.70