Assay Detail
Functional
CHEMBL699333
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cellular cholesterol biosynthesis using human fibroblasts in tissue culture
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.53 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70611 | AZALANSTAT | 2.0 | 1 | 10.05 |
| CHEMBL305220 | — | — | 1 | 8.10 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70611 | AZALANSTAT | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL305220 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 37.0 | nM | 7.43 |