Assay Detail
Functional
CHEMBL699423
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the production of Interleukin-1-beta from human peripheral blood monocytes stimulated with lipopolysaccharide (LPS)
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
2'-substituted chalcone derivatives as inhibitors of interleukin-1 biosynthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 5.77 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32856 | — | — | 1 | 6.66 |
| CHEMBL32746 | — | — | 1 | 6.51 |
| CHEMBL33548 | — | — | 1 | 6.45 |
| CHEMBL32857 | — | — | 1 | 6.39 |
| CHEMBL32236 | — | — | 1 | 6.30 |
| CHEMBL32444 | — | — | 1 | 6.24 |
| CHEMBL286855 | — | — | 1 | 6.23 |
| CHEMBL287041 | — | — | 1 | 6.22 |
| CHEMBL287856 | — | — | 1 | 6.21 |
| CHEMBL36302 | — | — | 1 | 6.16 |
| CHEMBL32120 | — | — | 1 | 6.13 |
| CHEMBL33744 | — | — | 1 | 6.10 |
| CHEMBL33665 | — | — | 1 | 6.09 |
| CHEMBL32207 | — | — | 1 | 6.01 |
| CHEMBL286582 | — | — | 1 | 6.00 |
| CHEMBL440657 | — | — | 1 | 5.97 |
| CHEMBL32192 | — | — | 1 | 5.96 |
| CHEMBL33241 | — | — | 1 | 5.94 |
| CHEMBL33655 | — | — | 1 | 5.89 |
| CHEMBL32204 | — | — | 1 | 5.88 |
| CHEMBL33885 | — | — | 1 | 5.87 |
| CHEMBL442345 | — | — | 1 | 5.85 |
| CHEMBL285174 | — | — | 1 | 5.82 |
| CHEMBL32387 | — | — | 1 | 5.79 |
| CHEMBL33551 | — | — | 1 | 5.78 |
| CHEMBL284558 | — | — | 1 | 5.78 |
| CHEMBL34786 | — | — | 1 | 5.78 |
| CHEMBL32509 | — | — | 1 | 5.78 |
| CHEMBL33298 | — | — | 1 | 5.77 |
| CHEMBL32259 | — | — | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32856 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL32746 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL33548 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL32857 | — | IC50 | = | 407.0 | nM | 6.39 |
| CHEMBL32236 | — | IC50 | = | 503.0 | nM | 6.30 |
| CHEMBL32444 | — | IC50 | = | 577.0 | nM | 6.24 |
| CHEMBL286855 | — | IC50 | = | 592.0 | nM | 6.23 |
| CHEMBL287041 | — | IC50 | = | 596.0 | nM | 6.22 |
| CHEMBL287856 | — | IC50 | = | 609.0 | nM | 6.21 |
| CHEMBL36302 | — | IC50 | = | 693.0 | nM | 6.16 |
| CHEMBL32120 | — | IC50 | = | 748.0 | nM | 6.13 |
| CHEMBL33744 | — | IC50 | = | 793.0 | nM | 6.10 |
| CHEMBL33665 | — | IC50 | = | 803.0 | nM | 6.09 |
| CHEMBL32207 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL286582 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL440657 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL32192 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL33241 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL33655 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL32204 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL33885 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL442345 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL285174 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL32387 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL32509 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL284558 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL33551 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL34786 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL33298 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL32259 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL33049 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL32144 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL32467 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL32353 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL34397 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL414831 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL287855 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL286336 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL32896 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL32231 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL287154 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL33943 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL32393 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL36301 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL32147 | 2'-HYDROXYCHALCONE | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL32339 | 4,2',4',6'-TETRAMETHOXYCHALCONE | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL285646 | — | IC50 | = | 5170.0 | nM | 5.29 |
| CHEMBL285621 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL33370 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL285241 | — | IC50 | = | 5750.0 | nM | 5.24 |