Assay Detail
Functional
CHEMBL699501
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against PAF-induced aggregation of human platelets suspended in buffer [washed platelets (WP)]
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.55 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118105 | — | — | 1 | 9.10 |
| CHEMBL407427 | — | — | 1 | 9.05 |
| CHEMBL116072 | — | — | 1 | 9.05 |
| CHEMBL117413 | — | — | 1 | 9.00 |
| CHEMBL299944 | — | — | 1 | 8.82 |
| CHEMBL325491 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118105 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL407427 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL116072 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL117413 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL299944 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL325491 | — | IC50 | = | 515.0 | nM | 6.29 |