Assay Detail
Functional
CHEMBL699531
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Concentration required for 50% inhibition of platelet aggregation of human gel-filtered platelets(GFP) in platelet aggregation assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nonpeptide glycoprotein IIb/IIIa inhibitors. 13. design and synthesis of an orally active pyrazolopiperazinone nonpeptide fibrinogen receptor antagonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.48 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL286172 | — | — | 1 | 8.30 |
| CHEMBL40502 | — | — | 1 | 8.05 |
| CHEMBL36961 | — | — | 1 | 7.96 |
| CHEMBL289800 | — | — | 1 | 7.82 |
| CHEMBL416239 | — | — | 1 | 7.66 |
| CHEMBL290182 | — | — | 1 | 7.60 |
| CHEMBL417700 | — | — | 1 | 7.35 |
| CHEMBL418424 | — | — | 1 | 6.92 |
| CHEMBL288521 | — | — | 1 | 6.60 |
| CHEMBL39579 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL286172 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL40502 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL36961 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL289800 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL416239 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL290182 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL417700 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL418424 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL288521 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL39579 | — | IC50 | = | 260.0 | nM | 6.58 |