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Assay Detail

CHEMBL699532

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration for inhibition of PAF-induced platelet aggregation in human platelet-rich plasma
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Tissue Plasma
Confidence 1 — Organism
Curated By Expert

Target

Homo sapiens (CHEMBL372)
Type ORGANISM
Organism Homo sapiens

Publication

Dual antagonists of platelet activating factor and histamine. 2. pyridine ring substitution of N-acetyl-4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidines
Wong JK, Piwinski JJ, Green MJ, Ganguly AK, Anthes JC, Billah M
Bioorg Med Chem Lett (1993) 3 : 1073 -1078
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.80 6.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL10855 1 6.55
CHEMBL275109 1 6.47
CHEMBL11158 1 6.22
CHEMBL269460 1 6.21
CHEMBL10971 SCH-37370 1 6.21
CHEMBL268695 1 6.16
CHEMBL11159 1 6.03
CHEMBL10826 1 5.97
CHEMBL11313 1 5.97
CHEMBL11136 1 5.83
CHEMBL11435 1 5.68
CHEMBL11001 1 5.64
CHEMBL268022 1 5.56
CHEMBL11055 1 5.52
CHEMBL275993 1 5.38
CHEMBL10903 1 5.22
CHEMBL274357 1 5.22
CHEMBL274153 1 5.17
CHEMBL10981 1 5.10
CHEMBL11222 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL10855 IC50 = 280.0 nM 6.55
CHEMBL275109 IC50 = 340.0 nM 6.47
CHEMBL11158 IC50 = 600.0 nM 6.22
CHEMBL269460 IC50 = 610.0 nM 6.21
CHEMBL10971 SCH-37370 IC50 = 610.0 nM 6.21
CHEMBL268695 IC50 = 690.0 nM 6.16
CHEMBL11159 IC50 = 940.0 nM 6.03
CHEMBL10826 IC50 = 1080.0 nM 5.97
CHEMBL11313 IC50 = 1070.0 nM 5.97
CHEMBL11136 IC50 = 1480.0 nM 5.83
CHEMBL11435 IC50 = 2080.0 nM 5.68
CHEMBL11001 IC50 = 2290.0 nM 5.64
CHEMBL268022 IC50 = 2730.0 nM 5.56
CHEMBL11055 IC50 = 3040.0 nM 5.52
CHEMBL275993 IC50 = 4130.0 nM 5.38
CHEMBL10903 IC50 = 6000.0 nM 5.22
CHEMBL274357 IC50 = 6000.0 nM 5.22
CHEMBL274153 IC50 = 6750.0 nM 5.17
CHEMBL10981 IC50 = 8000.0 nM 5.10
CHEMBL11222 IC50 >= 50000.0 nM -