Assay Detail
Binding
CHEMBL699544
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Inhibitory activity of compound against human plasma Kallikrein (PK)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of potent and selective inhibitors of human plasma kallikrein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.30 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1160813 | — | — | 1 | 8.70 |
| CHEMBL1160807 | — | — | 1 | 8.40 |
| CHEMBL1160809 | — | — | 1 | 8.30 |
| CHEMBL1160804 | — | — | 1 | 7.55 |
| CHEMBL1160808 | — | — | 1 | 7.05 |
| CHEMBL1160805 | — | — | 1 | 6.30 |
| CHEMBL1160803 | — | — | 1 | 4.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1160813 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1160807 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL1160809 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL1160804 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL1160808 | — | Ki | = | 89.0 | nM | 7.05 |
| CHEMBL1160805 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL1160803 | — | Ki | = | 15500.0 | nM | 4.81 |