Assay Detail
Functional
CHEMBL699553
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In vitro inhibition for TNF-alpha production from LPS-stimulated human whole blood
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of cyclic inhibitors of matrix metalloproteinases and TNF-alpha production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.62 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45631 | — | — | 1 | 5.92 |
| CHEMBL417537 | — | — | 1 | 5.75 |
| CHEMBL48258 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45631 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL417537 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL48258 | — | IC50 | = | 6500.0 | nM | 5.19 |