Assay Detail
Binding
CHEMBL699595
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Binding affinity against Kappa opioid receptor using [3H]U-69593 radioligand in mouse brain homogenates
12
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pyrrolooctahydroisoquinolines as potent and selective opioid receptor ligands: SAR analysis and docking studies
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.53 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2051964 | — | — | 1 | 8.02 |
| CHEMBL327956 | — | — | 1 | 7.15 |
| CHEMBL322181 | — | — | 1 | 6.77 |
| CHEMBL327745 | — | — | 1 | 6.51 |
| CHEMBL101516 | — | — | 1 | 6.35 |
| CHEMBL108076 | — | — | 1 | 6.30 |
| CHEMBL100729 | — | — | 3 | 5.89 |
| CHEMBL100911 | — | — | 1 | - |
| CHEMBL316863 | — | — | 1 | - |
| CHEMBL101623 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2051964 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL327956 | — | Ki | = | 70.4 | nM | 7.15 |
| CHEMBL322181 | — | Ki | = | 169.2 | nM | 6.77 |
| CHEMBL327745 | — | Ki | = | 312.0 | nM | 6.51 |
| CHEMBL101516 | — | Ki | = | 449.0 | nM | 6.35 |
| CHEMBL108076 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL100729 | — | Ki | = | 1298.0 | nM | 5.89 |
| CHEMBL100729 | — | Ki | = | 1340.0 | nM | 5.87 |
| CHEMBL100729 | — | Ki | = | 1340.0 | nM | 5.87 |
| CHEMBL100911 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL316863 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL101623 | — | Ki | > | 1000.0 | nM | - |