Assay Detail
Binding
CHEMBL699602
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Nitric Oxide Synthase Inhibitory activity tested against recombinant murine Inducible nitric oxide synthase (inducible isoform)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 4.42 | 5.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1202118 | — | — | 1 | 5.05 |
| CHEMBL1204421 | — | — | 1 | 4.60 |
| CHEMBL1202117 | — | — | 1 | 4.21 |
| CHEMBL1204426 | — | — | 1 | 4.21 |
| CHEMBL1202106 | — | — | 1 | 4.01 |
| CHEMBL2092928 | — | — | 1 | - |
| CHEMBL1204423 | — | — | 1 | - |
| CHEMBL1204422 | — | — | 1 | - |
| CHEMBL2113674 | — | — | 1 | - |
| CHEMBL2092929 | — | — | 1 | - |
| CHEMBL1202116 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1202118 | — | Ki | = | 8900.0 | nM | 5.05 |
| CHEMBL1204421 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL1202117 | — | Ki | = | 62000.0 | nM | 4.21 |
| CHEMBL1204426 | — | Ki | = | 61000.0 | nM | 4.21 |
| CHEMBL1202106 | — | Ki | = | 97000.0 | nM | 4.01 |
| CHEMBL2092928 | — | Ki | = | 910000.0 | nM | - |
| CHEMBL1204423 | — | Ki | = | 104000.0 | nM | - |
| CHEMBL1204422 | — | Ki | = | 3600000.0 | nM | - |
| CHEMBL2113674 | — | Ki | = | 1180000.0 | nM | - |
| CHEMBL2092929 | — | Ki | = | 103000.0 | nM | - |
| CHEMBL1202116 | — | Ki | = | 4700000.0 | nM | - |