Assay Detail
Binding
CHEMBL699604
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Tested for inhibition of rat brain inducible nitric oxide synthase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Nitric oxide synthase, inducible (CHEMBL3051) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.79 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11471 | L-NIO | — | 1 | 5.66 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 4.75 |
| CHEMBL227744 | NITROARGININE | 1.0 | 1 | 4.70 |
| CHEMBL7889 | L-NIL | — | 1 | 4.04 |
| CHEMBL127739 | — | — | 1 | - |
| CHEMBL340800 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11471 | L-NIO | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL256147 | TILARGININE | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL227744 | NITROARGININE | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL7889 | L-NIL | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL127739 | — | IC50 | = | 808000.0 | nM | - |
| CHEMBL340800 | — | IC50 | = | 2800000.0 | nM | - |