Assay Detail

CHEMBL699608

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Functional

Tested for the ability to inhibit Leukotriene B4 (LTB4) induced chemotaxis. (Test compound added to upper and lower wells)

ChEMBL ↗

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Target

Homo sapiens (CHEMBL372) ↗

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Primary target Homo sapiens

CHEMBL372

Anchored from Assay target.

Protein identity Homo sapiens

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Confidence	1 — Organism
Curated By	Intermediate

Target

Homo sapiens (CHEMBL372) ↗

Type	ORGANISM
Organism	Homo sapiens

Publication

Second-generation leukotriene B4 receptor antagonists related to SC-41930: heterocyclic replacement of the methyl ketone pharmacophore.

Penning TD, Djuric SW, Miyashiro JM, Yu S, Snyder JP, Spangler D, Anglin CP, Fretland DJ, Kachur JF, Keith RH.
J Med Chem (1995) 38 : 858 -868
PubMed 7699700 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.08	6.08

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL14823	SC-41390	—	1	6.08

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL14823	SC-41390	IC50	=	832.0	nM	6.08