Assay Detail
Functional
CHEMBL699668
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of K-Ras processing, farnesylation and/or geranylgeranylation in human PSN1 cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | PSN1 |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Protein farnesyl/geranylgeranyl transferase (CHEMBL2096991) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.21 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318626 | — | — | 1 | 7.00 |
| CHEMBL316673 | — | — | 1 | 6.68 |
| CHEMBL450336 | — | — | 1 | 6.66 |
| CHEMBL439047 | — | — | 1 | 6.64 |
| CHEMBL99901 | — | — | 1 | 6.50 |
| CHEMBL294888 | — | — | 1 | 6.47 |
| CHEMBL322435 | — | — | 1 | 5.89 |
| CHEMBL2111612 | — | — | 1 | 5.72 |
| CHEMBL323302 | — | — | 1 | 5.43 |
| CHEMBL400694 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318626 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL316673 | — | EC50 | = | 207.0 | nM | 6.68 |
| CHEMBL450336 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL439047 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL99901 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL294888 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL322435 | — | EC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL2111612 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL323302 | — | EC50 | = | 3730.0 | nM | 5.43 |
| CHEMBL400694 | — | EC50 | = | 8000.0 | nM | 5.10 |