Assay Detail
Binding
CHEMBL699701
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit [3H]-KA binding to Ionotropic glutamate receptor kainate from rat cortical membranes.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, kainate (CHEMBL2094119) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis, resolution, and biological evaluation of the four stereoisomers of 4-methylglutamic acid: selective probes of kainate receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.10 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 7.96 |
| CHEMBL288166 | 2S,4R-4-METHYLGLUTAMATE | — | 1 | 7.46 |
| CHEMBL85447 | — | — | 1 | 7.09 |
| CHEMBL41221 | — | — | 1 | 6.51 |
| CHEMBL289439 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275040 | KAINIC ACID | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL288166 | 2S,4R-4-METHYLGLUTAMATE | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL85447 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL41221 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL289439 | — | IC50 | = | 330.0 | nM | 6.48 |