Compound Detail
CHEMBL85447
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Basic Information
| ChEMBL ID | CHEMBL85447 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KRKRAOXTGDJWNI-IUYQGCFVSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
161.2
MW (Da)
-0.49
ALogP
3
HBA
3
HBD
100.6
PSA (Ų)
0.52
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate CHEMBL2094119 | IC50 | 7.09 | 7.09 | 82.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate | IC50 | = | 82.0 | nM | 7.09 | Ability to inhibit [3H]-KA binding to Ionotropic glutamate receptor kainate from... | 7629789 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7629789 | 10.1021/jm00014a002 | Glutamate receptor 1 | 2 |
| 7629789 | 10.1021/jm00014a002 | Glutamate receptor ionotropic, kainate | 1 |
| 15801843 | 10.1021/jm049092j | Metabotropic glutamate receptor 4 | 1 |
Data from ChEMBL 36 via Core Engine