Assay Detail
Binding
CHEMBL699703
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit the binding of [3H]-kainic acid radioligand to Ionotropic glutamate receptor kainate in rat brain membranes.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, kainate (CHEMBL2094119) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Heteroaryl analogues of AMPA. 2. Synthesis, absolute stereochemistry, photochemistry, and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.73 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 8.15 |
| CHEMBL310897 | — | — | 1 | 5.31 |
| CHEMBL85331 | — | — | 1 | - |
| CHEMBL316225 | — | — | 1 | - |
| CHEMBL315416 | — | — | 1 | - |
| CHEMBL83720 | — | — | 1 | - |
| CHEMBL313039 | — | — | 1 | - |
| CHEMBL86216 | — | — | 1 | - |
| CHEMBL312860 | — | — | 1 | - |
| CHEMBL315906 | — | — | 1 | - |
| CHEMBL84114 | — | — | 1 | - |
| CHEMBL82406 | — | — | 1 | - |
| CHEMBL85688 | — | — | 1 | - |
| CHEMBL315203 | — | — | 1 | - |
| CHEMBL276815 | (S)-AMPA | — | 1 | - |
| CHEMBL84132 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275040 | KAINIC ACID | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL310897 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL85331 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL316225 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL315416 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL83720 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL313039 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL86216 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL312860 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL315906 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL84114 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL82406 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL85688 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL315203 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL276815 | (S)-AMPA | IC50 | > | 100000.0 | nM | - |
| CHEMBL84132 | — | IC50 | > | 100000.0 | nM | - |