Assay Detail
Binding
CHEMBL699727
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Ionotropic glutamate receptor AMPA binding to human hippocampal homogenates at concentration of 5-7 uM
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Hippocampus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic AMPA (CHEMBL2096670) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
6-(4-pyridinyl)-1H-1,2,3-triazolo[4,5-d]-pyrimidin-4(5H)-one: a structurally novel competitive AMPA receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.15 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL155265 | DNQX | — | 1 | 6.55 |
| CHEMBL357121 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL155265 | DNQX | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL357121 | — | IC50 | = | 1800.0 | nM | 5.75 |