Compound Detail
CHEMBL357121
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Basic Information
| ChEMBL ID | CHEMBL357121 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NWVFCQRYIOXLFA-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
214.2
MW (Da)
0.47
ALogP
6
HBA
2
HBD
100.5
PSA (Ų)
0.61
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 2 meas. best 6.2
IC50 1 meas. best 5.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NON-PROTEIN TARGET CHEMBL3879801 | Kd | 6.2 | 6.14 | 631.0 | 2 |
| Glutamate receptor ionotropic AMPA CHEMBL2096670 | IC50 | 5.75 | 5.75 | 1800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NON-PROTEIN TARGET | Kd | = | 630.96 | nM | 6.2 | Ability to antagonize kainate-induced responses in frog oocyte | 7532226 |
| NON-PROTEIN TARGET | Kd | = | 831.76 | nM | 6.08 | Ability to antagonize AMPA-induced responses in frog oocytes | 7532226 |
| Glutamate receptor ionotropic AMPA | IC50 | = | 1800.0 | nM | 5.75 | Inhibition of Ionotropic glutamate receptor AMPA binding to human hippocampal ho... | 7532226 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7532226 | 10.1021/jm00004a003 | NON-PROTEIN TARGET | 4 |
| 7532226 | 10.1021/jm00004a003 | Glutamate receptor ionotropic AMPA | 1 |
Data from ChEMBL 36 via Core Engine