Assay Detail

CHEMBL678727

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Functional

Ability to antagonize AMPA-induced responses in frog oocytes

ChEMBL ↗

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Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Open DB target context

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Primary target NON-PROTEIN TARGET

CHEMBL3879801

Anchored from Assay target.

Protein identity NON-PROTEIN TARGET

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	frog
Cell Type	Oocyte
Confidence	1 — Organism
Curated By	Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗

Type	NON-MOLECULAR

Publication

6-(4-pyridinyl)-1H-1,2,3-triazolo[4,5-d]-pyrimidin-4(5H)-one: a structurally novel competitive AMPA receptor antagonist.

Subramanyam C, Ault B, Sawutz D, Bacon ER, Singh B, Pennock PO, Kelly MD, Kraynak M, Krafte D, Treasurywala A.
J Med Chem (1995) 38 : 587 -589
PubMed 7532226 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	6.08	6.08

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL357121	—	—	1	6.08

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL357121	—	Kd	=	831.76	nM	6.08