Assay Detail
Binding
CHEMBL699778
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the inhibition of [3H]-KA binding to Ionotropic glutamate receptor kainate from rat brain synaptic membrane.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, kainate (CHEMBL2094119) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Syntheses of trans-3-substituted-CCG-IV analogs and their characterization to ionotropic glutamate receptors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.93 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 8.37 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 6.92 |
| CHEMBL312192 | — | — | 1 | 5.89 |
| CHEMBL282842 | — | — | 1 | 5.80 |
| CHEMBL75640 | — | — | 1 | 5.52 |
| CHEMBL80628 | — | — | 1 | 5.40 |
| CHEMBL80376 | — | — | 1 | 5.00 |
| CHEMBL433333 | — | — | 1 | 4.50 |
| CHEMBL291278 | N-METHYL-D-ASPARTIC ACID (NMDA) | 2.0 | 1 | - |
| CHEMBL276815 | (S)-AMPA | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275040 | KAINIC ACID | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL575060 | GLUTAMIC ACID | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL312192 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL282842 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL75640 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL80628 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL80376 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL433333 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL291278 | N-METHYL-D-ASPARTIC ACID (NMDA) | IC50 | > | 100000.0 | nM | - |
| CHEMBL276815 | (S)-AMPA | IC50 | > | 100000.0 | nM | - |