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Assay Detail

CHEMBL699843

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
The inhibition of KB cell growth was determined
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KB
Confidence 1 — Organism
Curated By Expert

Target

KB (CHEMBL398)
Type CELL-LINE
Organism Homo sapiens

Publication

Benzimidazole ribonucleosides: design, synthesis, and antiviral activity of certain 2-(alkylthio)- and 2-(benzylthio)-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazoles.
Devivar RV, Kawashima E, Revankar GR, Breitenbach JM, Kreske ED, Drach JC, Townsend LB.
J Med Chem (1994) 37 : 2942 -2949
PubMed 8071942 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.46 4.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL609803 1 4.82
CHEMBL612192 1 4.72
CHEMBL608921 1 4.70
CHEMBL609478 1 4.60
CHEMBL610342 1 4.52
CHEMBL610966 1 4.52
CHEMBL611268 1 4.52
CHEMBL609513 1 4.39
CHEMBL610343 1 4.30
CHEMBL609212 1 4.22
CHEMBL611263 1 4.17
CHEMBL375530 DICHLORORIBOBENZIMIDAZOLE 1 4.00
CHEMBL610922 1 -
CHEMBL184 ACYCLOVIR 4.0 1 -
CHEMBL2311195 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL609803 IC50 = 15000.0 nM 4.82
CHEMBL612192 IC50 = 19000.0 nM 4.72
CHEMBL608921 IC50 = 20000.0 nM 4.70
CHEMBL609478 IC50 = 25000.0 nM 4.60
CHEMBL610342 IC50 = 30000.0 nM 4.52
CHEMBL610966 IC50 = 30000.0 nM 4.52
CHEMBL611268 IC50 = 30000.0 nM 4.52
CHEMBL609513 IC50 = 41000.0 nM 4.39
CHEMBL610343 IC50 = 50000.0 nM 4.30
CHEMBL609212 IC50 = 60000.0 nM 4.22
CHEMBL611263 IC50 = 68000.0 nM 4.17
CHEMBL375530 DICHLORORIBOBENZIMIDAZOLE IC50 = 100000.0 nM 4.00
CHEMBL610922 IC50 > 100000.0 nM -
CHEMBL184 ACYCLOVIR IC50 > 100000.0 nM -
CHEMBL2311195 IC50 > 100000.0 nM -