Assay Detail
Binding
CHEMBL699888
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Compound was tested for in vitro binding affinity against Ionotropic glutamate receptor AMPA using [3H]AMPA ligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2096617) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Mus musculus |
Publication
Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.25 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | — | 1 | 7.40 |
| CHEMBL279956 | QUISQUALATE | — | 1 | 7.10 |
| CHEMBL71073 | — | — | 1 | 6.47 |
| CHEMBL315663 | — | — | 1 | 6.32 |
| CHEMBL73698 | — | — | 1 | 6.22 |
| CHEMBL10339 | — | — | 1 | 5.75 |
| CHEMBL73069 | — | — | 1 | 4.50 |
| CHEMBL173847 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL279956 | QUISQUALATE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL71073 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL315663 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL73698 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL10339 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL73069 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL173847 | — | IC50 | > | 1000000.0 | nM | - |