Compound Detail
CHEMBL73069
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Basic Information
| ChEMBL ID | CHEMBL73069 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JRTOQOAGTSUNHA-UWTATZPHSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
251.0
MW (Da)
0.10
ALogP
5
HBA
3
HBD
109.6
PSA (Ų)
0.70
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Rattus norvegicus CHEMBL376 | IC50 | 6.82 | 6.82 | 150.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 6.82 | 5.66 | 150.0 | 2 |
| Glutamate receptor ionotropic, AMPA CHEMBL2096617 | IC50 | 4.5 | 4.5 | 32000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 150.0 | nM | 6.82 | In vitro binding affinity against Metabotropic glutamate receptor using [3H](S)-... | 9526567 |
| Rattus norvegicus | IC50 | = | 150.0 | nM | 6.82 | In vitro binding affinity against synaptic membrane from rat brain using [3H](S)... | 2552114 |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 32000.0 | nM | 4.5 | Compound was tested for in vitro binding affinity against Ionotropic glutamate r... | 9526567 |
| Unchecked | IC50 | = | 32000.0 | nM | 4.5 | In vitro binding affinity against synaptic membrane from rat brain using [3H]AMP... | 2552114 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2552114 | 10.1021/jm00130a005 | Unchecked | 2 |
| 9526567 | 10.1021/jm9706731 | Glutamate receptor ionotropic, AMPA | 1 |
| 9526567 | 10.1021/jm9706731 | Unchecked | 1 |
| 9526567 | 10.1021/jm9706731 | Rattus norvegicus | 1 |
| 2552114 | 10.1021/jm00130a005 | Glutamate receptor ionotropic, kainate | 1 |
| 2552114 | 10.1021/jm00130a005 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine