Assay Detail
Binding
CHEMBL711158
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In vitro binding affinity against Metabotropic glutamate receptor using [3H](S)-glutamic acid
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.63 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279956 | QUISQUALATE | — | 1 | 7.60 |
| CHEMBL73069 | — | — | 1 | 6.82 |
| CHEMBL73698 | — | — | 1 | 6.70 |
| CHEMBL71073 | — | — | 1 | 6.66 |
| CHEMBL173847 | — | — | 1 | 6.24 |
| CHEMBL10339 | — | — | 1 | 6.20 |
| CHEMBL315663 | — | — | 1 | 6.19 |
| CHEMBL13378 | (R,S)-AMPA | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279956 | QUISQUALATE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL73069 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL73698 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL71073 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL173847 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL10339 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL315663 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL13378 | (R,S)-AMPA | IC50 | > | 100000.0 | nM | - |